.page_fs-8__RUWoK{font-size:.5rem;line-height:.6875rem}.page_fs-8__RUWoK sup{font-size:.3333333333rem;top:-.1666666667rem}.page_fs-10__qOGta{font-size:.625rem;line-height:.859375rem}.page_fs-10__qOGta sup{font-size:.4166666667rem;top:-.2083333333rem}.page_fs-12__0AVO8{font-size:.75rem;line-height:1.03125rem}.page_fs-12__0AVO8 sup{font-size:.5rem;top:-.25rem}.page_fs-14__j0HPc{font-size:.875rem;line-height:1.203125rem}.page_fs-14__j0HPc sup{font-size:.5833333333rem;top:-.2916666667rem}.page_fs-16__9p2e4{font-size:1rem;line-height:1.375rem}.page_fs-16__9p2e4 sup{font-size:.6666666667rem;top:-.3333333333rem}.page_fs-18__6o_Jg{font-size:1.125rem;line-height:1.546875rem}.page_fs-18__6o_Jg sup{font-size:.75rem;top:-.375rem}.page_fs-20__lT9HO{font-size:1.25rem;line-height:1.71875rem}.page_fs-20__lT9HO sup{font-size:.8333333333rem;top:-.4166666667rem}.page_fs-24__KW18g{font-size:1.5rem;line-height:2.0625rem}.page_fs-24__KW18g sup{font-size:1rem;top:-.5rem}.page_fs-30__LObxR{font-size:1.875rem;line-height:2.578125rem}.page_fs-30__LObxR sup{font-size:1.25rem;top:-.625rem}.page_fs-36__VdDEM{font-size:2.25rem;line-height:3.09375rem}.page_fs-36__VdDEM sup{font-size:1.5rem;top:-.75rem}.page_fs-40__i4n6Q{font-size:2.5rem;line-height:3.4375rem}.page_fs-40__i4n6Q sup{font-size:1.6666666667rem;top:-.8333333333rem}.page_fs-48__g3w18{font-size:3rem;line-height:4.125rem}.page_fs-48__g3w18 sup{font-size:2rem;top:-1rem}.page_fs-70__x9tdF{font-size:4.375rem;line-height:6.015625rem}.page_fs-70__x9tdF sup{font-size:2.9166666667rem;top:-1.4583333333rem}.page_fs-76__GAFfx{font-size:4.75rem;line-height:6.53125rem}.page_fs-76__GAFfx sup{font-size:3.1666666667rem;top:-1.5833333333rem}@media(min-width:992px){.page_fs-lg-8__Rny0C{font-size:.5rem;line-height:.6875rem}.page_fs-lg-10__DpSE_{font-size:.625rem;line-height:.859375rem}.page_fs-lg-12__q2WfJ{font-size:.75rem;line-height:1.03125rem}.page_fs-lg-14__MrqCP{font-size:.875rem;line-height:1.203125rem}.page_fs-lg-16__1vQ36{font-size:1rem;line-height:1.375rem}.page_fs-lg-18__W2UnQ{font-size:1.125rem;line-height:1.546875rem}.page_fs-lg-20__qkHS2{font-size:1.25rem;line-height:1.71875rem}.page_fs-lg-24__LQfR0{font-size:1.5rem;line-height:2.0625rem}.page_fs-lg-30__TQG28{font-size:1.875rem;line-height:2.578125rem}.page_fs-lg-36__VIcao{font-size:2.25rem;line-height:3.09375rem}.page_fs-lg-40__mdjuI{font-size:2.5rem;line-height:3.4375rem}.page_fs-lg-48__GjNUk{font-size:3rem;line-height:4.125rem}.page_fs-lg-70__EgjOU{font-size:4.375rem;line-height:6.015625rem}.page_fs-lg-76__6aUFr{font-size:4.75rem;line-height:6.53125rem}}.page_mt-8__EJ_ZS{margin-top:.5rem}.page_mt-12__0Pnk8{margin-top:.75rem}.page_mt-14__kyAzq{margin-top:.875rem}.page_mt-16__GYSoD{margin-top:1rem}.page_mt-18__UTnqj{margin-top:1.125rem}.page_mt-20__NSzRw{margin-top:1.25rem}.page_mt-24__a677E{margin-top:1.5rem}.page_mt-34__xKqt2{margin-top:2.125rem}.page_mt-36__g9e4_{margin-top:2.25rem}.page_mt-40__u97NI{margin-top:2.5rem}.page_mt-48__i6k0l{margin-top:3rem}.page_mt-60__ssus6{margin-top:3.75rem}.page_mt-64__80lwL{margin-top:4rem}.page_mb-6__4X7up{margin-bottom:.375rem}@media(min-width:992px){.page_mb-lg-6__NZ0nw{margin-bottom:.375rem}}.page_mb-8__lW5CY{margin-bottom:.5rem}@media(min-width:992px){.page_mb-lg-8__lne4M{margin-bottom:.5rem}}.page_mb-12__52bg9{margin-bottom:.75rem}@media(min-width:992px){.page_mb-lg-12__lSEw6{margin-bottom:.75rem}}.page_mb-14__RxEcY{margin-bottom:.875rem}@media(min-width:992px){.page_mb-lg-14__10JH6{margin-bottom:.875rem}}.page_mb-16__k3KWz{margin-bottom:1rem}@media(min-width:992px){.page_mb-lg-16__dsW1_{margin-bottom:1rem}}.page_mb-18__Qegk2{margin-bottom:1.125rem}@media(min-width:992px){.page_mb-lg-18__imHOq{margin-bottom:1.125rem}}.page_mb-20__nqnZq{margin-bottom:1.25rem}@media(min-width:992px){.page_mb-lg-20__9LrWh{margin-bottom:1.25rem}}.page_mb-24__cMSoi{margin-bottom:1.5rem}@media(min-width:992px){.page_mb-lg-24__MznX5{margin-bottom:1.5rem}}.page_mb-30__LP5QJ{margin-bottom:1.875rem}@media(min-width:992px){.page_mb-lg-30__KNcGq{margin-bottom:1.875rem}}.page_mb-34__5rjo0{margin-bottom:2.125rem}@media(min-width:992px){.page_mb-lg-34__98Jgt{margin-bottom:2.125rem}}.page_mb-36__OfRfz{margin-bottom:2.25rem}@media(min-width:992px){.page_mb-lg-36___u0kp{margin-bottom:2.25rem}}.page_mb-40__huAqL{margin-bottom:2.5rem}@media(min-width:992px){.page_mb-lg-40___puyt{margin-bottom:2.5rem}}.page_mb-48__yw22L{margin-bottom:3rem}@media(min-width:992px){.page_mb-lg-48__zCwqA{margin-bottom:3rem}}.page_mb-60__qkCKz{margin-bottom:3.75rem}@media(min-width:992px){.page_mb-lg-60__fvkWj{margin-bottom:3.75rem}}.page_mb-64__biXXT{margin-bottom:4rem}@media(min-width:992px){.page_mb-lg-64__rvbDe{margin-bottom:4rem}}.page_pt-6__DFHP8{padding-top:.375rem}@media(min-width:992px){.page_pt-lg-6__aGEDq{padding-top:.375rem}}.page_pt-8__N2Rl0{padding-top:.5rem}@media(min-width:992px){.page_pt-lg-8__sV_S9{padding-top:.5rem}}.page_pt-12__XIMb7{padding-top:.75rem}@media(min-width:992px){.page_pt-lg-12__eMNHK{padding-top:.75rem}}.page_pt-14__K0jAa{padding-top:.875rem}@media(min-width:992px){.page_pt-lg-14__Mfkry{padding-top:.875rem}}.page_pt-16__msO_h{padding-top:1rem}@media(min-width:992px){.page_pt-lg-16__FpPJ9{padding-top:1rem}}.page_pt-18__uxSXK{padding-top:1.125rem}@media(min-width:992px){.page_pt-lg-18__d7o2g{padding-top:1.125rem}}.page_pt-20__kkQym{padding-top:1.25rem}@media(min-width:992px){.page_pt-lg-20__oVGR0{padding-top:1.25rem}}.page_pt-24__64e_s{padding-top:1.5rem}@media(min-width:992px){.page_pt-lg-24__RUe3x{padding-top:1.5rem}}.page_pt-30__Yqvke{padding-top:1.875rem}@media(min-width:992px){.page_pt-lg-30__R_WWF{padding-top:1.875rem}}.page_pt-34__pbJTZ{padding-top:2.125rem}@media(min-width:992px){.page_pt-lg-34__zUiLg{padding-top:2.125rem}}.page_pt-36__Ycmnl{padding-top:2.25rem}@media(min-width:992px){.page_pt-lg-36__sKF3e{padding-top:2.25rem}}.page_pt-40__MsuoB{padding-top:2.5rem}@media(min-width:992px){.page_pt-lg-40__bXaOh{padding-top:2.5rem}}.page_pt-48__s_Imm{padding-top:3rem}@media(min-width:992px){.page_pt-lg-48__YY6ub{padding-top:3rem}}.page_pt-60__xl2NB{padding-top:3.75rem}@media(min-width:992px){.page_pt-lg-60___pnTT{padding-top:3.75rem}}.page_pt-64__L30zB{padding-top:4rem}@media(min-width:992px){.page_pt-lg-64__JEyJK{padding-top:4rem}}.page_pb-8___c44S{padding-bottom:.5rem}.page_pb-12__rE4Uz{padding-bottom:.75rem}.page_pb-14__QsuwB{padding-bottom:.875rem}.page_pb-16__Tz058{padding-bottom:1rem}.page_pb-18__5l3K2{padding-bottom:1.125rem}.page_pb-20__WuFwj{padding-bottom:1.25rem}.page_pb-24__BZ08D{padding-bottom:1.5rem}.page_pb-34__guC8r{padding-bottom:2.125rem}.page_pb-40__0yqnV{padding-bottom:2.5rem}.page_pb-48__jW0wN{padding-bottom:3rem}.page_pb-60__6q6f2{padding-bottom:3.75rem}.page_pb-64__q2WPE{padding-bottom:4rem}.page_pb-110__7F3eT{padding-bottom:6.875rem}.page_page__ggdxV{background:var(--background)}.page_contentWrap__SoLj8{margin-top:24px;margin-inline:auto}.page_sectionHeading__oOPN5{margin:0;max-width:980px}.page_sectionHeading__oOPN5+.page_bulletList__DqoFO,.page_sectionHeading__oOPN5+.page_chartHeading__Lkge4{margin-top:10px}.page_sectionHeading__oOPN5+.page_sectionHeading__oOPN5{margin-top:18px}.page_bulletList__DqoFO{margin:0;padding-left:1.1rem}.page_bulletList__DqoFO li{margin-bottom:10px}.page_bulletList__DqoFO li::marker{color:#2e799b}.page_chartHeading__Lkge4{margin:20px 0 0;color:var(--brand-agios-blue,#2E799B);text-align:center;font-family:"Untitled Sans",var(--font-untitled-sans-fallback),"Public Sans",sans-serif;font-size:26px;font-style:normal;font-weight:700;line-height:120%;letter-spacing:-.2px}.page_chartWrap__Ay90v{margin-top:14px}.page_chartDesktop__BWebb{width:100%;height:auto;display:block}.page_chartMobile__h3qDF{display:none;width:100%;height:auto}.page_footnote__KNQOV{margin:12px auto 0;max-width:980px}.page_fullWidthFootnote__uV0hB{max-width:none;width:100%}.page_callout__JHCTT{margin-top:20px;margin-inline:auto;max-width:900px}.page_organSection__A3GCv{padding-top:48px;padding-bottom:64px}@media(max-width:767px){.page_organSection__A3GCv{padding-top:40px;padding-bottom:40px}}.page_ctaSection__HVqft{background:#f8f8f8;padding-top:64px}.page_ctaSection__HVqft .bottom-cta-cards{margin-top:0}@media(max-width:767px){.page_ctaSection__HVqft{padding-top:40px}}.page_organCardsGrid__Av6Ss{margin-top:16px;display:grid;grid-template-columns:repeat(4,minmax(0,1fr));grid-gap:16px;gap:16px;align-items:stretch}.page_organCard__Jatck{display:flex}.page_organCardImage__wzOYb{width:100%;height:auto;display:block}@media(max-width:991px){.page_contentWrap__SoLj8{margin-top:20px}.page_sectionHeading__oOPN5+.page_sectionHeading__oOPN5{margin-top:16px}.page_bulletList__DqoFO{padding-left:1rem}.page_bulletList__DqoFO li{margin-bottom:9px}.page_chartHeading__Lkge4{margin-top:18px;font-size:22px}.page_chartWrap__Ay90v{margin-top:12px}.page_callout__JHCTT{margin-top:18px}.page_organCardsGrid__Av6Ss{grid-template-columns:repeat(2,minmax(0,1fr));gap:14px}}@media(max-width:767px){.page_chartDesktop__BWebb{display:none}.page_chartMobile__h3qDF{display:block}.page_chartHeading__Lkge4{font-size:20px}.page_organCardsGrid__Av6Ss{grid-template-columns:1fr;gap:24px}.page_organCardImage__wzOYb{padding:0 50px}}